DRZ

Canadians with Waldenström’s Macroglobulinemia who meet inclusion requirements may want to consider participation in a new study of Beigene’s BGB-16673, a Bruton Tyrosine Kinase Targeted Protein Degrader.  To help in your understanding of a BTK Degrader, see our recent post comparing them to BTK inhibitors (BTKi). Official title of the study: A Phase 1/2, Open-Label, Dose Escalation and Expansion Study of the Bruton Tyrosine Kinases Targeted Protein Degrader BGB-16673 in Patients with B-cell Malignancies. Canadian Study Locations Now Recruiting: Calgary, AB:  Arthur Child Comprehensive Cancer Centre Edmonton, AB:  Cross Cancer Institute Québec, QC:  Université de Laval, Hôpital de l’enfant Jésus, Centre Integre de Cancerologie Vancouver, [...]

Bruton’s tyrosine kinase (BTK) inhibitors and BTK Degraders are two different approaches to targeting BTK, a key enzyme in the B-cell receptor signaling pathway, which is crucial for the survival and proliferation of B-cells. Both strategies are used in the treatment of B-cell malignancies and autoimmune diseases, but they operate through distinct mechanisms. BTK Inhibitors Mechanism of Action:  Inhibition.  BTK inhibitors are small molecules that bind to the active site of BTK, preventing its phosphorylation (a biological reaction in which phosphate is added to an organic molecule) and subsequent activation. This inhibits downstream signaling pathways that are essential for B-cell proliferation [...]

From the science desk, a report on: The 12th International Workshop on Waldenström’s Macroglobulinemia (IWWM-12) that took place in Prague, Czech Republic from October 17-19, 2024 where leading experts gathered to discuss the latest advances in the understanding and treatment of WM, and The 66th annual meeting and exposition of the American Society of Hematology (ASH) that took place in San Diego, California from December 7-10, 2024. The WMFC reviewed all of the IWWM-12 abstracts submitted in Prague and found that very many of the presentations/posters simply confirmed the work of others.  For example, several abstracts confirmed three WM lineages: B [...]