WM Information for Physicians
Our goal is to make the selection of information here useful to the medical community at large. Thus the information here may not necessarily be easily consumed by the public. But all are welcome to this collection of WM-related information.
Canadian Clinical Trials for WM Treatment
Two clinical trials are available for WM patients at various sites across Canada:
- https://clinicaltrials.gov/ct2/show/NCT04624906: Treatment naive patients; Bendamustine + Rituximab, plus one year of Acalabrutinib
- https://clinicaltrials.gov/ct2/show/NCT04728893: R/R patients; Nemtabrutinib (a non-covalent BTK inhibitor)
International Workshop on WM 2022 (iwWM) Summary
A summary of the 11th International Workshop on WM (iwWM) held October, 2022, has been published at https://link.springer.com/article/10.1007/s12254-023-00876-3. Click on the “Download PDF” box on the right.
Multi-omic Analysis Yields Significant WM Insights
Partially funded by the WMFC and presented at ASH in December, 2022, this research identified three subtypes of WM.
The full abstract that Dr. Hunter presented at ASH is available here.
Two other WM-related abstracts using the multiomic analysis from Dr. Hunter’s research were also presented at ASH:
- An in-depth investigation into why epigenomic regulation is so important to MYD88 mutations is available here
- The data also has been applied to investigating why ibrutinib (and by extension other BTK inhibitors) may result in long Progression-Free Survival (PFS); that abstract is available here
Video: The Latest on WM and its Treatment
Dr. Steve Treon of the Dana-Farber Cancer Institute presents a thorough summary of the latest knowledge of WM and its current and upcoming treatments. See https://youtu.be/JCrdW4VpNpw.
A Canadian Perspective on the Treatment of WM
This journal article by a set of researchers from across Canada provides an overview of treatment options for WM, and their usage in current (2022) Canadian WM treatment. See https://www.mdpi.com/1718-7729/29/10/560.