Waldenstrom’s Macroglobulinemia often develops over a long period of time (years), and some people have no symptoms at all.

However, most people will gradually develop symptoms of WM for two main reasons:

The abnormal cells are filling up the bone marrow or collecting in the lymph nodes or spleen.

Large amounts of IgM are circulating in the bloodstream or targeting tissue and nerves.

When they do occur, signs and symptoms may include:

  • Easy bruising

  • Bleeding from the nose or the gums

  • Fatigue

  • Weight loss

  • Numbness in your hands or feet

  • Fever

  • Headache

  • Shortness of breath

  • Changes in vision

  • Confusion

  • Enlarged Lymph nodes

  • Low hemoglobin


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Risk Factors

Being older

Waldenstrom’s macroglobulinemia can occur at any age, but it’s most often diagnosed in adults 65 and older.

Being male

Males are more likely to be diagnosed with Waldenstrom’s macroglobulinemia.

Being white

White people are more likely to develop the disease, compared with people of other races.

Having a family history of lymphoma

If you have a relative who has been diagnosed with Waldenstrom’s macroglobulinemia or another type of B-cell lymphoma, you may have an increased risk.

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